Please use this identifier to cite or link to this item: http://hdl.handle.net/10525/1632

 Title: Theoretical Hyperbolic Model of a Partial Agonism: Explicit Formulas for Affinity, Efficacy and Amplification Authors: Milanov, PeterPencheva, Nevena Keywords: ModelAgonistAffinityEfficacyAmplificationReceptor Issue Date: 2011 Publisher: Institute of Mathematics and Informatics Bulgarian Academy of Sciences Citation: Serdica Journal of Computing, Vol. 5, No 4, (2011), 333p-358p Abstract: The quantitative analysis of receptor-mediated effect is based on experimental concentration-response data in which the independent variable, the concentration of a receptor ligand, is linked with a dependent variable, the biological response. The steps between the drug–receptor interaction and the subsequent biological effect are to some extent unknown. The shape of the fitting curve of the experimental data may give some in-sights into the nature of the concentration–receptor–response (C-R-R) mechanism. It can be evaluated by non-linear regression analysis of the experimental data points of the independent and dependent variables, which could be considered as a history of the interaction between the drug and receptors. However, this information is not enough to evaluate such important parameters of the mechanism as the dissociation constant (affinity) and efficacy. There are two ways to provide more detailed information about the C-R-R mechanism: (i) an experimental way for obtaining data with new or URI: http://hdl.handle.net/10525/1632 ISSN: 1312-6555 Appears in Collections: Volume 5 Number 4

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