Case-control study Genotypes Gibbs distribution Likelihood ratio test
Issue Date:
2007
Publisher:
Institute of Mathematics and Informatics Bulgarian Academy of Sciences
Citation:
Pliska Studia Mathematica Bulgarica, Vol. 18, No 1, (2007), 293p-314p
Abstract:
In this article, we propose a novel candidate-gene association test that utilizes a set of tightly linked single nucleotide polymorphisms (SNPs). This is a powerful likelihood ratio test based on Gibbs random field model. We use simulation studies to evaluate the type I error rate of our proposed test, and compare its power with that of other candidate-gene association tests. The simulation results show that our proposed test has correct type I error rate, and is more powerful than the other tests in most cases considered in our simulation studies.
